发给老马备查:
& R& L: |" V5 I! W滴水察海(69304838) 15:23:23( Z8 E" x8 ~9 q8 s& n
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱5 k" s0 K7 z$ B3 j: n( g
吉非替尼和S-1连用的依据; \( c0 S1 h) M7 I- K
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.* U9 ^& ?& U. u' J* G5 _/ ~3 u
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
$ e# P2 \" ]$ V3 h4 b% K- R8 I这样是不是推理出,耐药后,可以用S-1和培美了?% [, R/ F- Y( ~5 j( k: p. w
结论:
' R. T1 J, d7 T# x6 ]# o1 W) p如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |