发给老马备查:
; H7 Y$ j' \) ^! K1 o( E滴水察海(69304838) 15:23:23+ M+ x) Y+ l) Z5 J' i9 {$ C- Q
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱& J' `" }4 J- G; v
吉非替尼和S-1连用的依据+ a0 h+ b2 V: {, z# U- x+ V' z% N
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro. l& X/ n& W/ H! I0 }6 A+ _ v
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达3 H/ F+ p& {4 m2 e, {
这样是不是推理出,耐药后,可以用S-1和培美了?
& V; h) s8 u$ I2 @! `5 E0 N- }% K3 h结论:
1 r! F0 O1 \2 H, @( _5 f如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |