脑部放疗，上午比下午敏感许多！
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; l+ v+ D# V& G: [1 T" rCancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9.
5 d1 ?! q0 I* U* }Gamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?& {. g; Z$ f! C: d: ]1 e7 B' s
Rahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.1 Y, X. @ z! D" p
SourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.% b5 D$ X; ]2 k! X7 a1 H
' X% Q8 O: k' tAbstract
# O7 g% u4 A' v, ^BACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time./ M Y) e: X/ m
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METHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic./ m! G* }9 {, p
+ e" Z' x, J6 N" u6 KRESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).' E2 D! z) a3 L V: ]' G/ ^/ K
+ G7 Y1 G2 }3 s9 P0 q3 lCONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.6 \/ R5 |. F3 r# l! ^1 B5 d
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妈妈化疗的艰难时刻，倍瑞博营养液带
当母亲被确诊为肺腺癌四期的那一刻，我们全家如坠冰窟。随之而来的化疗更是煎熬——
希望给没有阅读过的人一些体会
本文来自于此书，只是做一些摘抄，分享给深陷迷茫的人。文中观点真实与否，效果
无靶点 her2扩增 二线白紫耐药后怎么
家父今年62岁，22年11月份颈部淋巴结穿刺，确诊肺低分化腺癌，分期是TxN3M1，基因检测
父亲肺鳞癌，cT3N0M1a，ⅣA，脑转移
父亲2025年6月中旬因为头痛，一侧肢体不灵活入院，做了增强核磁，发现右侧额叶占位（3
120万一针的抗癌药在肿瘤患者体内就
作者：Tony
一提起CAR-T，很多人都会想到的是其120万一针的恐怖价格，它是治愈癌症的
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显身卡
