EGFR相关资料汇总（更新于2020.7.3）
（中国已上市EGFR抑制剂）https://mp.weixin.qq.com/s/LvUTRh5w6H3pgiBGxg6f3g（EGFR及基因检测基础知识）http://www.yuaigongwu.com/forum.php?mod=viewthread&tid=12690&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline
（Tagrisso（Osimertinib，AZD9291）耐药对策）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=28473&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline
（靶向药剂量换算）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=30049&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline
（最通俗易懂的靶向药整理《转载》）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=35262&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline
（HER2突变、扩增和高表达）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58481&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=e69a90a4
（EGFR突变NSCLC患者的MET扩增耐药机制）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58485&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=f9300efa
（NSCLC向SCLC的组织学转化）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58490&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=f76406e6
（靶向药轮换（三）T790M的时空异质性）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58492&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=0d7462a5
（外周血的EGFR突变检测）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58494&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=b942c5c9
（再次给药和进展后继续治疗）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58497&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=190fb39c
（EGFR突变的耐药对策）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58498&_dsign=712f88f6
（小细胞肺癌转化机制和治疗）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58505&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=e459f744
（EGFR抑制剂实用表（2017-5-7））https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58553&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=056f06ee
（EGFR-TKI辅助治疗对驱动基因和耐药机制的影响）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58570&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=aadcf0a2
（T790M和C797S反式突变的不同类型）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58573&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=71304d5f
（AZD3759用药说明【整理版】）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=29778&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=6f225b3d
（EGFR脑转新药Lazertinib）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=59292&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=a3c5b946
（肺癌新药艾氟替尼）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58560&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=2be23fa5
（第四代EGFR抑制剂CH7233163）https://mp.weixin.qq.com/s/3v2NO6EAO53vP09Olxz78g
第一代EGFR靶向药包括：易瑞沙=吉非替尼=ZD1839，特罗凯=厄洛替尼，凯美纳=盐酸埃克替尼
（易瑞沙的耐药性于注意事项）http://www.yuaigongwu.com/thread-38934-1-1.html
（这些肺癌患者服用易瑞沙10年以上）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58504&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=60875f2d
（吉非替尼（易瑞沙）使用说明书）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58823&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=8a30d6ef
（厄洛替尼（特罗凯）使用说明书）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58820&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=d7fcbd87
（特罗凯联合贝伐单抗 1+1>2?）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=59097&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=a6ada097
（埃克替尼（凯美纳）使用说明书）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58819&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=2ab6fb80
第二代EGFR靶向药包括：阿法替尼=BIBW2992，达克替尼=PF299804
（阿法替尼（BIBW2992）简介及药品说明书）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=29185&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline
（阿法替尼（2992）用药说明【整理版】）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=29189&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline
（深入解析阿法替尼）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58502&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=1143bdcb
（阿法替尼联合贝伐单抗方案）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58562&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=c93f56b9
（克唑替尼和阿法替尼的剂量调整）https://mp.weixin.qq.com/s/NlEwkFpFE5cmqm91pxIEtQ
（阿法替尼经鼻腔给药突破血脑屏障）https://mp.weixin.qq.com/s/S6OacG8lytlA7_qHg81Y8g
（半夏泻心汤预防阿法替尼所致腹泻）https://mp.weixin.qq.com/s/yMbGTp4Fj7zqGK3nU1EWLA
（阿法替尼的大剂量间歇给药方案）https://mp.weixin.qq.com/s/vaPSqkvAn8J0t0BePaxlKQ
（经阿法替尼联合贝伐单抗方案治疗患者的T790M状态变化）https://mp.weixin.qq.com/s/ArXlLMAzqxmf7ZHDkjHzkg
（阿法替尼联合芦可替尼一期临床结果）https://mp.weixin.qq.com/s/woSXaPydZBYx1_TESN3Fug
（达可替尼Dacomitinib（PF-00299804））https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=29500&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline
（达可替尼）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58482&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=610eef53
（达可替尼咸鱼翻身？）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58503&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=a5a35894
（达可替尼间歇给药方案）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58563&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=6c012a8d
(达克替尼药品说明书)https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=61048&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=51ace575
第三代EGFR靶向药包括：泰瑞沙=奥希替尼=AZD9291，阿美乐=甲磺酸阿美替尼
（第三代EGFR靶向药的原发耐药机制）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58551&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=bc119f84
（第三代EGFR抑制剂）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58557&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=ccecec05
奥希替尼相关汇总：
1.（AZD9291(奥希替尼）用药说明【整理版】)https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=29191&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline
2.（《转阿梁的精辟分析》）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=57295&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=44c771fb
3.（延缓和克服AZD9291耐药临床初步结果）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58483&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=eae55d41
4.（AZD9291联合MET TKI的耐药问题）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58486&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=08f0de77
5.（奥希替尼相关的TAPOs）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58500&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=522d4ae8
6.（深入解析奥希替尼）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58501&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=53ef7f6d
7.（米哚妥林有望克服奥希替尼耐药）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58506&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=c4460f0f
8.（【ESMO 2017】奥希替尼一线治疗的III期临床结果）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58559&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=15e94583
9.（【WCLC 2017】奥希替尼耐药机制研究进展）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58564&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=2b03439b
10.（奥希替尼耐药之后还能继续吗？）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58575&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=cc91452c
11.（奥希替尼和吉非替尼轮换方案）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58571&_dsign=24a7b656
12.（奥希替尼联合阿法替尼方案）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58561&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=e0f4a60d
13.（【AACR 2017】奥希替尼耐药机制）https://mp.weixin.qq.com/s/hzOK4FZtpla4UguDDMclaw
14.（【经典病例】奥希替尼联合克唑替尼治疗NSCLC）https://mp.weixin.qq.com/s/2YdAcsfRHy9VpiKOkzzX_Q
15.（奥希替尼AURA3临床脑转移患者数据解读）https://mp.weixin.qq.com/s/D4iZ2gJ75NkgUm1KR0vRgA
16.（奥希替尼联合沃利替尼方案）https://mp.weixin.qq.com/s/8fuo3Ta_hiF4vKpwGLqq7Q
17.（奥希替尼（泰瑞沙）导致的QTc间期延长）https://mp.weixin.qq.com/s/Yo8aDQg7b0wo_6kzy5XHww
18.（奥希替尼诱导的血小板减少症）https://mp.weixin.qq.com/s/MqpLK4g5sOuTplqBirDpjA
19.（布格替尼联合司美替尼克服C797S突变导致的奥希替尼耐药）https://mp.weixin.qq.com/s/uwYEpWF-8ttf8Z8NeMHoOQ
20.（118名服用奥希替尼患者的中位生存期长达6年！）https://mp.weixin.qq.com/s/RPUnMajFs5Bs2Ltoxyfe1Q
21.（奥希替尼耐药新机制：Ex19Del/G724S突变）https://mp.weixin.qq.com/s/xaU4ipFyknqNts7JNF6mbw
22.（EGFR耐药研究：TATTON临床数据）https://mp.weixin.qq.com/s/ICLCQkVWVF1ZcL56XxAgew
23.（PARP抑制剂克服奥希替尼耐药的临床前研究）https://mp.weixin.qq.com/s/RCx-MvG8RSYlqssMW0SvDg
24.（奥希替尼新耐药机制：HER2 16外显子跳跃突变）https://mp.weixin.qq.com/s/Qj9emyw1nSWjPN-_hGa67Q
25.（奥希替尼之融合基因耐药机制）https://mp.weixin.qq.com/s/whP1IAQSvJQOTtDsrPaGig
26.（奥希替尼耐药机制之EGFR G796突变）https://mp.weixin.qq.com/s/ODcQq8wX208vfj5xm0mheg
27.（【ESMO Asia 2019】奥希替尼AURA3研究OS结果）https://mp.weixin.qq.com/s/YHd8vM7V2RiEawl1vLF2Gg
28.（【ESMO Asia 2019】奥希替尼联合沃利替尼临床数据更新）https://mp.weixin.qq.com/s/vD--NE8TgvyVnUpezJ7p2Q
29.（奥希替尼引起的心脏毒性）https://mp.weixin.qq.com/s/10lO-h0MFTh9EnsFOL-tEg
30.（奥希替尼和吉非替尼轮换方案的一些思考）https://mp.weixin.qq.com/s/EwIm4QzG7ctyGBey4uHuJQ
31.（奥希替尼引起的皮肤血管炎）https://mp.weixin.qq.com/s/TVAtxmNVqJH9ViC4PXVLIg
32.（奥希替尼耐药机制之EGFR L718Q/V突变）https://mp.weixin.qq.com/s/uyLKUkkiSJDgA9g5KeAX4A
33.（奥希替尼的TREM研究结果）https://mp.weixin.qq.com/s/a4bTxQK0s1xFeGxq1ZNUuw
34.（奥希替尼联合贝伐珠单抗一线治疗EGFR突变NSCLC）https://mp.weixin.qq.com/s/WO7Tuumfs8a7R883OFbSZQ
35.（奥希替尼治疗T790M阳性的EGFR复合突变NSCLC）https://mp.weixin.qq.com/s/veL78uNuTspfW1iZw_53Rw
36.（奥希替尼导致心力衰竭的处置）https://mp.weixin.qq.com/s/LN8rO0QtXKLJm6AkUsD-Mw
37.（肺腺癌向肺鳞癌转化是奥希替尼的耐药机制吗？）https://mp.weixin.qq.com/s/0KOfHK1AAa3sKGTEN0SQFA
38.（1-2代EGFR靶向药没有耐药就切换到奥希替尼）https://mp.weixin.qq.com/s/yYyfka2Kzrrk0-jciADPTg
一些病例参考：
（EGFR与EML4-ALK基因突变共存型非小细胞肺癌1例）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=15507&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline
（每个肺癌患者都是独一无二的）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58484&extra=page%3D2%26filter%3Dauthor%26orderby%3Ddateline&_dsign=e4d8486f
（【首例报道】阿法替尼和奥希替尼耐药后吉非替尼有效！）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58555&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=da8ab3a2
（Poziotinib的EGFR Exon 20突变临床数据振奋人心）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58565&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=4eb96a0b
（找到、抓住和解决主要矛盾）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58566&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=76bd9a41
（服用奥希替尼后肿瘤缩小但胸水增加，算有效吗？）https://www.yuaigongwu.com/forum.php?mod=viewthread&tid=58574&extra=page%3D1%26filter%3Dauthor%26orderby%3Ddateline&_dsign=9f693714
（C797S突变导致的第三代EGFR-TKIs耐药后化疗）https://mp.weixin.qq.com/s/9IzA76Cjc3pWMtchiENCOg
（【案例】奥希替尼耐药后上免疫联合化疗有效后进展）https://mp.weixin.qq.com/s/de0u8SXaIVQy8Ym1DzlPqw
（明洁的治疗史——奥希替尼的复敏）https://mp.weixin.qq.com/s/AweSmGrQxKhHxRqFZNGVgA
（蓝天的治疗史—易瑞沙和奥希替尼的轮换）https://mp.weixin.qq.com/s/-hDxZFddyI2-QXIokQBExA
（一例合并HER2扩增的奥希替尼耐药NSCLC）https://mp.weixin.qq.com/s/XOzLoM0y5ZYTOUTNFwpC7w
太全了，感谢LZ分享 很棒，好好看看https://majia.yuaigongwu.com/public/emotion/face_001.png 谢谢分享资料 感谢分享 想问一下 如果术后直接上三代奥西替尼是不是耐药后就没有可用的药了？ 感谢楼主分享https://majia.yuaigongwu.com/public/emotion/face_081.png Nina7835 发表于 2021-04-09 06:44
感谢分享 想问一下 如果术后直接上三代奥西替尼是不是耐药后就没有可用的药了？
不是的，耐药之后可以做基因检测，通过基因检测发现是什么导致耐药，如果有靶点可以继续吃药。 看了几晚上了 辛苦了，感谢！先学习。 感谢分享